What is the most important information I should know about Endep (amitriptyline)?
Do not use this medication if you are allergic to amitriptyline, or if you have recentlyhad a heart attack.Do not use amitriptyline if you have taken cisapride (Propulsid) or used an MAOinhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline(Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.
You may have thoughts about suicide when you first start taking an antidepressant,especially if you are younger than 24 years old. Your doctor will need to check you at regularvisits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: moodor behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable,agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, orhave thoughts about suicide or hurting yourself.
What should I discuss with my healthcare provider before taking Endep (amitriptyline)?
Do not use this medication if you are allergic to amitriptyline, or if you have recentlyhad a heart attack.Do not use amitriptyline if you have taken cisapride (Propulsid) or used an MAOinhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline(Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious,life-threatening side effects can occur if you take amitriptyline before the MAO inhibitor hascleared from your body.
Before taking amitriptyline, tell your doctor if you are allergic to any drugs, or if youhave:
heart disease;
a history of heart attack, stroke, or seizures;
bipolar disorder (manic-depression);
schizophrenia or other mental illness;
diabetes (amitriptyline may raise or lower blood sugar);
overactive thyroid;
glaucoma; or
problems with urination.
If you have any of these conditions, you may need a dose adjustmentor special tests to safely take amitriptyline.
You may have thoughts about suicide when you first start taking an antidepressant,especially if you are younger than 24 years old. Tell your doctor if you have worseningsymptoms of depression or suicidal thoughts during the first several weeks of treatment, orwhenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood orsymptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks oftreatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tellyour doctor if you are pregnant or plan to become pregnant during treatment.Amitriptyline can pass into breast milk and may harm a nursing baby. Do not use thismedication without telling your doctor if you are breast-feeding a baby.Do not give this medication to anyone under 18 years old without the advice of adoctor.